Endocrine Abstracts

The data of etiology and clinical characteristics of hypopituitarism in different countries differes. The aim of the study is to investigate etiology and some clinical characteristics of patients with hypopituitarism that were treated in the Clinical center of Vojvodina. The study was conducted as a retrospective study. There were 32 males and 28 female patients. Mean age was 52.2±17.5 years. Data was analized before and after substitution of hypopituitarism. Patients wer...

Introduction: Long-term therapy with bisphosphonates is considered a risk factor for the development of atypical fractures of the femur. One of the mechanisms of these fractures is excessive suppression of bone metabolism. The supplementation dose of vitamin D and calcium could have an impact on the degree of suppression of bone turnover.The aim: To determine whether the presence or dose of supplementation with vitamin D and calcium during antiresorptive...

Several studies have pointed to increased morbidity and mortality in patients with hypopituitarism, particularly from cardiovascular diseases, regardless of the application of the substitution therapy. The aim of this study was to present clinical characteristics and cardiovascular risk of our patients with hypopituitarism during 20 years of follow-up.Methods: Sixty patients with hypopituitarism without patients with acromegaly and Cushing disease were a...

Introduction and objective: Cardiovascular mortality is high in acromegaly. Our aim in this study was to determine the levels of the new cardiovascular marker in active acromegaly patients, the mean platelet volume (MPV) values before and after octreotide acetate LAR treatment.Material and methods: Thirty-six patients with active acromegaly who presented at the endocrinology department (mean age 46.0±14.0 years and mean BMI: 30.4±5.1 kg/m2...

Primary hyperparathyroidism is an autonomous form of hyperparathyroidism, whose characteristics are: increased secretion of parathyroid hormone with clinical signs of hypercalcemic syndrome and various organ lesions, including bones.Case report: A 51-year-old Caucasian female presented with walking difficulties, polyuria, polydipsia, palpitations and headaches. Examination showed thoracic spine hyperkyphosis with consecutive chest deformity, staggered wa...

Metabolic and immunological disturbances may be associated with hyperprolactinemia.Aim: The aim of this study was examination the presence of some metabolic and immunological disturbances, like as the changes in and body composition, as risk factors for development of atherosclerosis, in young women with hyperprolactinemia.Material and methods: The investigation was performed as prospective study in a group of 20 premenopausal wome...

Adrenal tumours form a very heterogeneous group by their origin, clinical presentation, size and biological potential.The aim of our retrospective study was the epidemiological analysis of the patients with adrenal tumours. We analyzed the gender, age, localisation, clinical presentation, and in patients who were treated surgically- the type of the intervention, patohystological and immunohystochemical finding from the 01.01.2000 to 01.01.2008. The linea...

Background and aims: Foot lesions (amputations, ulcerations) are the consequence of neuro-vascular complications. Cardiovascular risk factors are similar for both. Thus, we carried out a prospective 5-year study to examine the effects of established complications and classical risk factors on mortality in diabetic patients.Materials and methods: During the previous 5 years we analyzed 244 patients attending a diabetes clinic. The International Working Gr...

Introduction: L thyroxin treatment of CH is monitored by free T4 (fT4) which should be above mid normal range for the assay. It is not clear whether these doses are adequate for regulating the metabolic disturbances accompanying CH.Aim: To determine whether T4 therapy leads to improvement of metabolic parameters in CH.Materials and methods: This was a retrospective study. Study group comprised of 60 hypopituitary patients with CH, ...

Introduction: Biological casuses of levothyroxine (LT4) malabsorption are well known. Congestive heart failure, gastrointestinal diseases, pregnancy, medication or dietary interference are the most commonly known causes of poor oral absorption of LT4. However, when substitution therapy with LT4 fails we need to be more exploratory.Case description: Female, born in 1987, BH 164 cm, BW 73kg, in 2010 she was presented as M. Basedowi and in october 2011 near...